Syrrx's microvolume crystallization

WO/2006/101851A2	MICROFLUIDIC SYSTEM The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
US20060094119	Microfluidic system The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
6994749	Microfluidic device for parallel delivery and mixing of fluids A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a...
US20060003439	Microfluidic system The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
6964867	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
6916372	Microvolume device employing fluid movement by centrifugal force A microfluidic device comprising: a substrate shaped so as to provide the device with an axis of rotation about which the device may be rotated; and a plurality of microvolumes at least partially...
6872250	Microvolume crystallization method employing multiple lumens A method for determining crystallization conditions for a material, the method comprising: taking a microfluidic device comprising one or more lumens having microvolume dimensions and a plurality...
6869792	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided which comprises: performing a plurality of fermentations, each fermentation in a different sample vessel; and performing a further processing step on the plurality of fermented...
6837927	Microvolume device employing fluid movement by centrifugal force A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a...
6837926	Device for detecting precipitate formation in microvolumes A microfluidic device is provided that comprises: a card shaped substrate having first and second opposing faces; one or more microvolumes at least partially defined by a first face of the card...
6811609	Microvolume device employing fluid movement by centrifugal force in different directions A microfluidic device is provided that comprises: a substrate; one or more microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume, a second...
6797056	Microfluidic method employing delivery of plural different fluids to same lumen A microfluidic method is provided that comprises: delivering first and second fluids to a lumen of a microfluidic device such that the first and second fluids flow adjacent to each other within the...
6780240	Method for causing fluid movement by centrifugal force A microfluidic method is provided that comprises: taking a microfluidic device comprising a plurality of microvolumes; and causing movement of material in a same manner within the plurality of...
6761766	Method for parallel delivery and mixing of fluids by rotating a microfluidic device A microfluidic method comprising: taking a microfluidic device comprising a substrate, and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a...
6719840	In situ crystal growth and crystallization A method is provided for determining crystallization conditions for a material, the method comprising: taking a plurality of different crystallization samples in an enclosed microvolume, the...
WO/2002/101127A1	IN SITU CRYSTAL GROWTH AND ANALYSIS Methods and devices are provided for performing crystallization experiments and analyzing the results of the crystallization experiments in microfluidic devices including a method that comprises:...
US20020164653	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
WO/2002/075277A2	METHOD FOR PERFORMING MULTIPLE PROCESSING STEEPS IN A SINGLE VESSEL A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
US20020132286	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided which comprises: performing a plurality of fermentations, each fermentation in a different sample vessel; and performing a further processing step on the plurality of fermented...

BACE - summary

7384773	Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers...
7244708	Inhibitors of memapsin 2 and use thereof Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
US20070149763	Beta secretase exosite binding peptides and methods for identifying beta secretase modulators The present invention provides the crystal structure of BACE-1 complexed with both an active site inhibitor and an exosite peptide containing the core sequence YPYFI. The crystal structure shows...
7217556	Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE...
US20070099273	Refolded recombinant beta-secretase crystals and methods for preparing and using the same The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline...
EP1327143B1	CRYSTAL STRUCTURE OF BACE AND USES THEREOF Abstract not available for EP1327143 Abstract of corresponding document: WO0225276 This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE),...
7166454	Codon-optimized β-secretase and methods of refolding and processing The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. Polypeptides used herein are derived from human BACE...
US20060136141	Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells...
WO/2006/018287A1	THREE-DIMENSIONAL STRCTURE OF THE HUMAN ASPARTYL PROTEASE BETA-SITE AMYLOID PRECURSOR-PROTEIN-CLEAVING ENZYME 2 (BACE2), METHODS AND USE THEREOF The present invention concerns the aspartyl protease beta-site amyloid precursor protein­cleaving enzyme 2 (BACE2), in particular, the three-dimensional structure of BACE2. Methods of expression,...
US20040096950	Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this...
WO/2004/011641A2	CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this...
US20040014194	Beta-secretase crystals and methods for preparing and using the same The present invention relates to the expression, purification and crystallization of glycosylated β-secretase protein and a complex thereof. The crystals of the invention are useful, inter alia,...
6545127	Catalytically active recombinant memapsin and methods of use thereof Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
WO/2003/012089A2	CRYSTAL STRUCTURE OF BETA−SITE APP CLEAVING ENZYME (BACE) AND USE THEREOF Disclosed and claimed are novel BACE proteins, crystal structures thereof, nucleic acid molecules therefor, and methods for making and using and uses of the same, especially for ascertaining...
US20020055459	Crystal structure of bace and uses thereof This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents...
WO/2002/025276A1	CRYSTAL STRUCTURE OF BACE AND USES THEREOF This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents...