June 2008 publications

WO/2008/074227A1	SYNTHETIC ION CHANNELS Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also...
7390808	Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of...
US20080146513	Synthetic Ion Channels Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also...
EP1932907A1	Crystal structure of the catalytic domain of tolloid-like protease 1 and uses thereof The present invention relates to methods for cloning, expression, purification and crystallization of the catalytic domain of TLL1 (TLL1cd). The present inventors have solved the first human TLL1...
WO/2008/068534A2	CRYSTAL STRUCTURE The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...
US20080139449	X-Ray Structure of Human Fpps and Use For Selecting Fpps Binding Compounds The present invention relates to crystalline human farnesyl diphosphate synthase (FPPS), to the three-dimensional structure of free FPPS as well as the three-dimensional structures of FPPS in...
EP0891551B1	PROTEIN PHOSPHATASE-1 CATALYTIC SUBUNIT INTERACTIONS
7386398	Hepatitis C Virus NS5B polymerase inhibitor binding pocket The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding...
7384773	Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers...
7384759	Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methyltransferases The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the...
WO/2008/067223A2	IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F...
WO/2008/067045A2	CRYSTALS AND STRUCTURES OF RON KINASE The present invention provides machine readable media embedded with the three- dimensional molecular structure coordinates of RONKD and subsets thereof, including binding pockets, methods of using...
WO/2008/065138A1	NOVEL INSULIN CRYSTAL AND METHOD FOR PREPARING THE CRYSTAL The invention concerns a crystal comprising insulin characterised in the crystal being grown in the presence of a chaotropic agent provided that the crystal is not grown in the presence of urea and...
7383135	Methods of designing inhibitors for JNK kinases The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of...
7381804	G-CSF analog compositions and methods The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions...

May 2008 publications

US20080124808	Crystallization and structure of a plant peptide deformylase This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.
US20080124746	Methods and compositions relating to anthrax pathogenesis The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal...
US20080124740	Three dimensional coordinates of hypoxia inducible factor 1 alpha (HIF-1 alpha)-prolyl hydroxylase (EGLN1) and uses thereof The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate...
US20080124275	Crystalline Form of Fatty Acid Amide Hydrolase (Faah) The present invention is directed to FAAH crystals in complex with the inhibitor methoxyarachidonyl fluorophosphonate (MAFP) and to the use of these crystals to determine the three-dimensional...
7378498	Protein encoded by a nucleic acid A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided...
US20080113422	Crystallographic Structure Of Tcpraca And Uses Therefor The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided,...
US20080112946	Catalytically active recombinant memapsin and methods of use thereof Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
WO/2008/052387A1	STARCH BINDING DOMAIN AND USE THEREOF The present invention relates to a starch binding domain, a recombinant protein and a complex thereof. The present invention also relates to a method for separating a recombinant protein comprising...
WO/2008/052277A1	CRYSTALLINE COMPOSITION OF GM-CSF/GM-CSFR The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony...
US20080108793	Novel purified FabI polypeptides from fransicella tularensis The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The...
EP1573000B1	CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI)
7369946	Method of identifying inhibitors of Tie-2 The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the...
7368269	Crystallization of MAPK/ERK Kinase 2 Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses.