US20080124808 | Crystallization and structure of a plant peptide deformylase
This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide. |
US20080124746 | Methods and compositions relating to anthrax pathogenesis
The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal... |
US20080124740 | Three dimensional coordinates of hypoxia inducible factor 1 alpha (HIF-1 alpha)-prolyl hydroxylase (EGLN1) and uses thereof
The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate... |
US20080124275 | Crystalline Form of Fatty Acid Amide Hydrolase (Faah)
The present invention is directed to FAAH crystals in complex with the inhibitor methoxyarachidonyl fluorophosphonate (MAFP) and to the use of these crystals to determine the three-dimensional... |
7378498 | Protein encoded by a nucleic acid
A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided... |
US20080113422 | Crystallographic Structure Of Tcpraca And Uses Therefor
The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided,... |
US20080112946 | Catalytically active recombinant memapsin and methods of use thereof
Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been... |
WO/2008/052387A1 | STARCH BINDING DOMAIN AND USE THEREOF
The present invention relates to a starch binding domain, a recombinant protein and a complex thereof. The present invention also relates to a method for separating a recombinant protein comprising... |
WO/2008/052277A1 | CRYSTALLINE COMPOSITION OF GM-CSF/GM-CSFR
The present invention relates generally to the field of crystallography. More particularly, the present invention provides crystalline forms of a complex between granulocyte macrophage-colony... |
US20080108793 | Novel purified FabI polypeptides from fransicella tularensis
The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The... |
EP1573000B1 | CRYSTAL STRUCTURE OF GLUTAMATE RACEMASE (MURI) |
7369946 | Method of identifying inhibitors of Tie-2
The present invention relates to polypeptides which comprise the ligand binding domain of Tie-2, crystalline forms of these polypeptides and the use of these crystalline forms to determine the... |
7368269 | Crystallization of MAPK/ERK Kinase 2
Provided are crystals relating to human mitogen-activated protein kinase kinase2 (MAPKK2), also known as MAPK/ERK Kinase2 (MEK2) and its various uses. |
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