Friday, July 18, 2008

June 2008 publications

WO/2008/074227A1

SYNTHETIC ION CHANNELS
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also...

7390808

Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of...

US20080146513

Synthetic Ion Channels
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also...

EP1932907A1

Crystal structure of the catalytic domain of tolloid-like protease 1 and uses thereof
The present invention relates to methods for cloning, expression, purification and crystallization of the catalytic domain of TLL1 (TLL1cd). The present inventors have solved the first human TLL1...

WO/2008/068534A2

CRYSTAL STRUCTURE
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...

US20080139449

X-Ray Structure of Human Fpps and Use For Selecting Fpps Binding Compounds
The present invention relates to crystalline human farnesyl diphosphate synthase (FPPS), to the three-dimensional structure of free FPPS as well as the three-dimensional structures of FPPS in...

EP0891551B1

PROTEIN PHOSPHATASE-1 CATALYTIC SUBUNIT INTERACTIONS

7386398

Hepatitis C Virus NS5B polymerase inhibitor binding pocket
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding...

7384773

Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers...

7384759

Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methyltransferases
The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the...

WO/2008/067223A2

IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F...

WO/2008/067045A2

CRYSTALS AND STRUCTURES OF RON KINASE
The present invention provides machine readable media embedded with the three- dimensional molecular structure coordinates of RONKD and subsets thereof, including binding pockets, methods of using...

WO/2008/065138A1

NOVEL INSULIN CRYSTAL AND METHOD FOR PREPARING THE CRYSTAL
The invention concerns a crystal comprising insulin characterised in the crystal being grown in the presence of a chaotropic agent provided that the crystal is not grown in the presence of urea and...

7383135

Methods of designing inhibitors for JNK kinases
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of...

7381804

G-CSF analog compositions and methods
The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions...