WO/2008/074227A1 | SYNTHETIC ION CHANNELS
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also... |
7390808 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of... |
US20080146513 | Synthetic Ion Channels
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also... |
EP1932907A1 | Crystal structure of the catalytic domain of tolloid-like protease 1 and uses thereof
The present invention relates to methods for cloning, expression, purification and crystallization of the catalytic domain of TLL1 (TLL1cd). The present inventors have solved the first human TLL1... |
WO/2008/068534A2 | CRYSTAL STRUCTURE
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the... |
US20080139449 | X-Ray Structure of Human Fpps and Use For Selecting Fpps Binding Compounds
The present invention relates to crystalline human farnesyl diphosphate synthase (FPPS), to the three-dimensional structure of free FPPS as well as the three-dimensional structures of FPPS in... |
EP0891551B1 | PROTEIN PHOSPHATASE-1 CATALYTIC SUBUNIT INTERACTIONS |
7386398 | Hepatitis C Virus NS5B polymerase inhibitor binding pocket
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding... |
7384773 | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers... |
7384759 | Methods and compositions for determinig enzymatic activity and specificity of chalcone O-methyltransferases
The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the... |
WO/2008/067223A2 | IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F... |
WO/2008/067045A2 | CRYSTALS AND STRUCTURES OF RON KINASE
The present invention provides machine readable media embedded with the three- dimensional molecular structure coordinates of RONKD and subsets thereof, including binding pockets, methods of using... |
WO/2008/065138A1 | NOVEL INSULIN CRYSTAL AND METHOD FOR PREPARING THE CRYSTAL
The invention concerns a crystal comprising insulin characterised in the crystal being grown in the presence of a chaotropic agent provided that the crystal is not grown in the presence of urea and... |
7383135 | Methods of designing inhibitors for JNK kinases
The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site-binding pockets of... |
7381804 | G-CSF analog compositions and methods
The present invention relates to granulocyte colony-stimulating factor (“G-CSF”) hybrid molecules which retain the internal core helices of G-CSF. Also provided are pharmaceutical compositions... |
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