Glucocorticoid Receptor - summary

7241868	Crystallization of Glucocorticoid Receptor Provided are crystals relating to human Glucocorticoid Receptor and its various uses.
7238778	Crystallized glucocorticoid receptor ligand binding domain polypeptide and screening methods employing same A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning...
US20070020684	Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand...
US20050181362	Crystallized glucocorticoid receptor ligand binding domain polypeptide and screening methods employing same A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning...
WO/2003/090666A2	GLUCOCORTICOID RECEPTOR PROTEIN CRYSTALS The present invention is in the fields of biotechnology, protein purification and crystallization, x-ray diffraction analysis, three-dimensional computer molecular modeling and rational drug...
WO/2003/015692A2	CRYSTALLIZED GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN POLYPEPTIDE AND SCREENING METHODS EMPLOYING SAME A method of modifying a test nuclear receptor (NR) polypeptide is disclosed. The method provides a test NR polypeptide sequence having a characteristic that is targeted for modification; aligning...

VEGFR - summary

US20050197492	Crystal structure of VEGFRKD: ligand complexes and methods of use thereof Polypeptides containing the kinase domain of a VEGFR are described. Also described are crystal structures of these polypeptides, including the crystal structures of VEGFR2KD:ligand complexes. The...
6849721	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
WO/2004/092217A1	CRYSTAL STRUCTURE OF VEGFRKD: LIGAND COMPLEXES AND METHODS OF USE THEREOF Polypeptides containing the kinase domain of a VEGFR are described. Also described are crystal structures of these polypeptides, including the crystal structures of VEGFR2KD: ligand complexes. The...
6794146	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
6784285	Modifications of the VEGF Receptor-2 Protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
6753416	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
US20020164641	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
US20020127538	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
US20020051965	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
6316603	Modifications of the VEGF receptor-2 protein and methods of use A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...
WO/2000/014105A1	MODIFICATIONS OF THE VEGF RECEPTOR-2 PROTEIN AND METHODS OF USE A 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), a key enzyme in angiogenesis, has been...

ACE - summary

WO/2007/080400A2	ACE N-DOMAIN CRYSTAL The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes,...
US20060174816	Crystal structure of an angiotensin-converting enzyme (ace) and uses thereof The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and...
US20040209344	Crystal structure of angiotensin-converting enzyme-related carboxypeptidase The invention relates to molecules or molecular complexes which comprise binding pockets of angiotensin-converting enzyme-related carboxypeptidase or its homologues. The invention relates to a...
WO/2004/024765A1	CRYSTAL STRUCTURE OF AN ANGIOTENSIN-CONVERTING ENZYME (ACE) AND USES THEREOF The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and...
WO/2004/023270A2	CRYSTAL STRUCTURE OF ANGIOTENSIN-CONVERTING ENZYME-RELATED CARBOXYPEPTIDASE The invention relates to molecules or molecular complexes which comprise binding pockets of angiotensin-converting enzyme-related carboxypeptidase or its homologues. The invention relates to a...

Ribosome structures - summary

US20060136146	MODULATORS OF RIBOSOMAL FUNCTION AND IDENTIFICATION THEREOF The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20050272681	Ribosome structure and protein synthesis inhibitors The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20050234227	Ribosome structure and protein synthesis inhibitors The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20050233349	Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof The present invention is broadly directed to methods of screening ribosomal protein L 11 /GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution...
US20050154538	Crystal structure of the 30S ribosome and its use The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
US20050036997	RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20040265984	Methods of growing crystals of free, antibiotic-complexed, and substrate-complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals Methods of growing crystals of free, antibiotic complexed, or ribosomal substrate complexed large ribosomal subunits, coordinates defining the three-dimensional atomic structure thereof and methods...
US20040034207	Crystal structure of antibiotics bound to the 30S ribosome and its use The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 to which are bound...
US20030232779	Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
US20030171327	Determination and uses of the atomic structures of ribosomes and ribosomal subunits and their ligand complexes The present invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as the crystals produced by such methods. The x-ray diffraction patterns of...
US20030153002	Ribosome structure and protein synthesis inhibitors The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20030099955	Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution...
US20030027315	Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, coordinates defining the 3D atomic structure thereof and methods of utilizing such coordinates for rational...
US20020188108	X-ray crystal structures of functional ribosome complexes containing transfer RNA and model messenger RNAs and methods of use Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 5.5 Angstrom resolution. Many details of...
US20020106660	Crystal structure of the 30s ribosome and its use The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 with unit cell dimensions of...
US20020086308	Ribosome structure and protein synthesis inhibitors The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution...
US20020072861	Crystal structure of antibiotics bound to the 30S ribosome and its use The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P4 1 2 1 2 to which are bound...

Cytochrome P450 - summary

US20070179716	Crystal structure of cytochrome P450 3A4 and uses thereof The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds...
WO/2007/052049A2	CRYSTAL STRUCTURE OF CYTOCHROME P450 AND USES THEREOF The present invention relates to crystals of CYP450 and computer-assisted methods for redesigning ligands of CYP450.
7148046	Crystal structure of cytochrome P450 The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds...
WO/2006/130781A2	CRYSTAL OF A CYTOCHROME-LIGAND COMPLEX AND METHODS OF USE The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes...
US20060234365	Methods of purification of cytochrome P450 proteins The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from...
US20060116826	Crystals of cytochrome P450 2C9, structures thereof and their use The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be...
WO/2005/105842A2	CRYSTAL STRUCTURE OF CYTOCHROME P450 3A4 AND USES THEREOF The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1 - 4. The structure may be used in to model the interaction of...
US20050164341	Methods of purification of cytochrome p450 proteins and of their crystallizing The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from...
US20050159901	Crystal structure of cytochrome P450 The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds...
US20050032119	Crystal structure of cytochrome P450 The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds...
US20040243319	Crystal structure of cytochrome P450 The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds...
WO/2004/096857A2	CRYSTALS OF CYTOCHROME P450 2C9, STRUCTURES THEREOF AND THEIR USE The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be...
WO/2004/038015A1	CRYSTAL STRUCTURE OF CYTOCHROME P450 3A4 AND ITS USE The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds...
US20040053383	Crystals of cytochrome P450 2C9, structures thereof and their use The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide...
WO/2003/102192A1	METHODS OF PURIFICATION OF CYTOCHROME P450 PROTEINS AND OF THEIR CRYSTALLIZING The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from...
US20030170842	Crystals of cytochrome P450 2C9, structures thereof and their use The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide...
WO/2003/035693A2	CRYSTALS OF CYTOCHROME P450 2C9, STRUCTURES THEREOF AND THEIR USE The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide...

Trilateral patent office meeting

Patent protection for structural genomics-related inventions

Vinarov SD; J Struct Funct Genomics; 2003;4(2-3):191-209

Recently there have been some important developments with respect to the patentability of inventions in the field of structural genomics. The leaders of the European Patent Office (EPO), Japan Patent Office (JPO) and the United States Patent Office (USPTO) came together for a trilateral meeting to conduct a comparative study on protein 3-dimensional (3-D) structure related claims in an effort to come to a mutual understanding about

Patent protection for protein structure analysis

Shimbo I, Nakajima R, Yokoyama S, Sumikura K.; Nat Biotechnol; 2004 Jan;22(1):109-12

Three national patent offices have consulted on patents that cover protein three-dimensional structural data and pharmacophores, with significant implications for the biotechnology industry.

HIV proteins - summary

WO/2007/030637A2	HIV GP120 CRYSTAL STRUCTURE AND ITS USE TO IDENTIFY IMMUNOGENS The present disclosure relates to stabilized forms of the HIV gpl20 envelope protein in complex with the broadly neutralizing CD4-binding site antibody bl2, to crystalline forms of the stabilized...
WO/2007/030518A2	CONFORMATIONALLY STABILIZED HIV ENVELOPE IMMUNOGENS AND TRIGGERING HIV-1 ENVELOPE TO REVEAL CRYPTIC V3-LOOP EPITOPES Stabilized forms of gpl20 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and...
WO/2002/034909A2	ENGINEERED CHIMERA OF HIV PROTEIN FRAGMENTS AND USES THEREOF The subject invention encompasses novel proteins related to the human immunodeficiency virus (HIV−1) gp41 protein and to methods of use thereof. For example, the proteins may be utilized in the...

c-Abl - summary

US20060030017	Three-dimensional structure of c-Abl The present invention concerns c-Abl, in particular, the three-dimensional structure of c-Abl containing an active DFG conformation. The atomic coordinates of c-Abl possessing this active DFG motif...
US20050107298	Crystals and structures of c-Abl tyrosine kinase domain The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of AblKD and variants and subsets thereof, including binding pockets,...
WO/2004/107114A2	CRYTALS AND STRUCTURES OF C-ABL TRYOSINE KNASE DOMAIN The present invention provides machine readable media embedded with the three­dimensional molecular structure coordinates of Ab1KD and variants and subsets thereof, including binding pockets,...

PDEs - summary

US20070015270	Crystalline PDE4D2 catalytic domain complex, and methods for making and employing same The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure...
US20070015205	Crystal structure of phosphodiesterase 5 and use thereof The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5...
WO/2005/103241A1	CRYSTAL STRUCTURE OF 3', 5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 9A (PDE9A) AND USES THEREOF The present invention related to a crystal structure of a phosphodiesterase 9A (PDE9A)/PDE9A ligand complex and their uses in identifying PDE9A modulators, including PDE9A ligand compounds. The...
WO/2005/087919A1	CRYSTAL STRUCTURE OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PDE10A) AND USES THEREOF Crystal structure of phosphodiesterase 10A (PDE10A), and the 3-D atomic coordinates of the PDE10A binding domain, as described and used for the identification of ligands, including PDE10A...
US20050202550	Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE10A) and uses thereof Crystal structure of phosphodiesterase 10A (PDE10A), and the 3-D atomic coordinates of the PDE10A binding domain, as described and used for the identification of ligands, including PDE10A...
US20050202549	Crystal structure The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present...
WO/2005/083069A1	PDE2 CRYSTAL STRUCTURES FOR STRUCTURE BASED DRUG DESIGN Crystalline compositions of Phosphodiesterase Type 2 (PDE2), particularly of the PDE2 catalytic domain, and amino acid sequences utilized to form such crystalline compositions, which are used to...
US20050079548	Ligand development using PDE4B crystal structures The use of PDE4B crystals and strucural information for identifying molecular scaffolds and for developing ligands that bind to and modulate PDE4B is described.
US20050075795	Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE1B) and uses thereof Crystal structures of phosphodiesterase 1B (PDE1B), and the 3-D atomic coordinates of the PDE1B binding domain, are described and used to obtain PDE1B ligands, including PDE1B inhibitors. The...
WO/2004/097010A1	CRYSTAL OF PDE5, ITS CRYSTAL STRUCTURE AND ITS USE IN DRUG DESIGN The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present...
WO/2004/087906A1	CRYSTAL STRUCTURE OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (PDE1B) AND USES THEREOF Crystal structures of phosphodiesterase 1B (PDE1B), and the 3-D atomic coordinates of the PDE1B binding domain, are described and used to obtain PDE1B ligands, including PDE1B inhibitors. The...
US20040082052	Crystal structure The present invention relates to the soakable crystal structures of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present...
WO/2003/038080A1	CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF The present invention relates , inter alia to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5...

Syrrx's microvolume crystallization

WO/2006/101851A2	MICROFLUIDIC SYSTEM The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
US20060094119	Microfluidic system The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
6994749	Microfluidic device for parallel delivery and mixing of fluids A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a...
US20060003439	Microfluidic system The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.
6964867	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
6916372	Microvolume device employing fluid movement by centrifugal force A microfluidic device comprising: a substrate shaped so as to provide the device with an axis of rotation about which the device may be rotated; and a plurality of microvolumes at least partially...
6872250	Microvolume crystallization method employing multiple lumens A method for determining crystallization conditions for a material, the method comprising: taking a microfluidic device comprising one or more lumens having microvolume dimensions and a plurality...
6869792	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided which comprises: performing a plurality of fermentations, each fermentation in a different sample vessel; and performing a further processing step on the plurality of fermented...
6837927	Microvolume device employing fluid movement by centrifugal force A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a...
6837926	Device for detecting precipitate formation in microvolumes A microfluidic device is provided that comprises: a card shaped substrate having first and second opposing faces; one or more microvolumes at least partially defined by a first face of the card...
6811609	Microvolume device employing fluid movement by centrifugal force in different directions A microfluidic device is provided that comprises: a substrate; one or more microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume, a second...
6797056	Microfluidic method employing delivery of plural different fluids to same lumen A microfluidic method is provided that comprises: delivering first and second fluids to a lumen of a microfluidic device such that the first and second fluids flow adjacent to each other within the...
6780240	Method for causing fluid movement by centrifugal force A microfluidic method is provided that comprises: taking a microfluidic device comprising a plurality of microvolumes; and causing movement of material in a same manner within the plurality of...
6761766	Method for parallel delivery and mixing of fluids by rotating a microfluidic device A microfluidic method comprising: taking a microfluidic device comprising a substrate, and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a...
6719840	In situ crystal growth and crystallization A method is provided for determining crystallization conditions for a material, the method comprising: taking a plurality of different crystallization samples in an enclosed microvolume, the...
WO/2002/101127A1	IN SITU CRYSTAL GROWTH AND ANALYSIS Methods and devices are provided for performing crystallization experiments and analyzing the results of the crystallization experiments in microfluidic devices including a method that comprises:...
US20020164653	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
WO/2002/075277A2	METHOD FOR PERFORMING MULTIPLE PROCESSING STEEPS IN A SINGLE VESSEL A method is provided for determining crystallization conditions for a protein, the method comprising: performing in a same fermentation apparatus 2 or more separate fermentations where each...
US20020132286	Method and apparatus for performing multiple processing steps on a sample in a single vessel A method is provided which comprises: performing a plurality of fermentations, each fermentation in a different sample vessel; and performing a further processing step on the plurality of fermented...

BACE - summary

7384773	Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers...
7244708	Inhibitors of memapsin 2 and use thereof Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
US20070149763	Beta secretase exosite binding peptides and methods for identifying beta secretase modulators The present invention provides the crystal structure of BACE-1 complexed with both an active site inhibitor and an exosite peptide containing the core sequence YPYFI. The crystal structure shows...
7217556	Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE...
US20070099273	Refolded recombinant beta-secretase crystals and methods for preparing and using the same The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline...
EP1327143B1	CRYSTAL STRUCTURE OF BACE AND USES THEREOF Abstract not available for EP1327143 Abstract of corresponding document: WO0225276 This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE),...
7166454	Codon-optimized β-secretase and methods of refolding and processing The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. Polypeptides used herein are derived from human BACE...
US20060136141	Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease An inhibitor bound form of human beta secretase, also known as memapsin 2 and BACE, particularly in a glycosylated form as expressed in Chinese hamster ovary (CHO), HEK293 cells, or in insect cells...
WO/2006/018287A1	THREE-DIMENSIONAL STRCTURE OF THE HUMAN ASPARTYL PROTEASE BETA-SITE AMYLOID PRECURSOR-PROTEIN-CLEAVING ENZYME 2 (BACE2), METHODS AND USE THEREOF The present invention concerns the aspartyl protease beta-site amyloid precursor protein­cleaving enzyme 2 (BACE2), in particular, the three-dimensional structure of BACE2. Methods of expression,...
US20040096950	Crystal structure of beta site APP cleaving enzyme (BACE) and methods of use thereof The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this...
WO/2004/011641A2	CRYSTAL STRUCTURE OF BETA-SITE APP-CLEAVING ENZYME (BACE) MUTANTS AND USES THEREOF The present application discloses and claims mutant BACE proteins, recombinant BACE proteins, processes for crystallizing BACE and in particular to its crystal structure and to the uses of this...
US20040014194	Beta-secretase crystals and methods for preparing and using the same The present invention relates to the expression, purification and crystallization of glycosylated β-secretase protein and a complex thereof. The crystals of the invention are useful, inter alia,...
6545127	Catalytically active recombinant memapsin and methods of use thereof Methods for the production of purified, catalytically active, recombinant memapsin 2 have been developed. The substrate and subsite specificity of the catalytically active enzyme have been...
WO/2003/012089A2	CRYSTAL STRUCTURE OF BETA−SITE APP CLEAVING ENZYME (BACE) AND USE THEREOF Disclosed and claimed are novel BACE proteins, crystal structures thereof, nucleic acid molecules therefor, and methods for making and using and uses of the same, especially for ascertaining...
US20020055459	Crystal structure of bace and uses thereof This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents...
WO/2002/025276A1	CRYSTAL STRUCTURE OF BACE AND USES THEREOF This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents...