US20070179716 | Crystal structure of cytochrome P450 3A4 and uses thereof
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds... |
WO/2007/052049A2 | CRYSTAL STRUCTURE OF CYTOCHROME P450 AND USES THEREOF
The present invention relates to crystals of CYP450 and computer-assisted methods for redesigning ligands of CYP450. |
7148046 | Crystal structure of cytochrome P450
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds... |
WO/2006/130781A2 | CRYSTAL OF A CYTOCHROME-LIGAND COMPLEX AND METHODS OF USE
The teachings relates to the three-dimensional structure of a crystal of a cytochrome protein complexed with a ligand. The three-dimensional structure of four cytochrome P450 2A6-ligand complexes... |
US20060234365 | Methods of purification of cytochrome P450 proteins
The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from... |
US20060116826 | Crystals of cytochrome P450 2C9, structures thereof and their use
The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be... |
WO/2005/105842A2 | CRYSTAL STRUCTURE OF CYTOCHROME P450 3A4 AND USES THEREOF
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1 - 4. The structure may be used in to model the interaction of... |
US20050164341 | Methods of purification of cytochrome p450 proteins and of their crystallizing
The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from... |
US20050159901 | Crystal structure of cytochrome P450
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds... |
US20050032119 | Crystal structure of cytochrome P450
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Tables 1-4. The structure may be used in to model the interaction of compounds... |
US20040243319 | Crystal structure of cytochrome P450
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds... |
WO/2004/096857A2 | CRYSTALS OF CYTOCHROME P450 2C9, STRUCTURES THEREOF AND THEIR USE
The present invention provides co-crystals of cytochrome P450 2C9 proteins and a ligand such as warfarin which has been crystallised to provide a high resolution structure. The structure may be... |
WO/2004/038015A1 | CRYSTAL STRUCTURE OF CYTOCHROME P450 3A4 AND ITS USE
The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds... |
US20040053383 | Crystals of cytochrome P450 2C9, structures thereof and their use
The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide... |
WO/2003/102192A1 | METHODS OF PURIFICATION OF CYTOCHROME P450 PROTEINS AND OF THEIR CRYSTALLIZING
The invention provides a method for the purification of cytochrome P450 molecules, the method comprising expressing in a host cell culture a cytochrome P450 molecule; recovering said cells from... |
US20030170842 | Crystals of cytochrome P450 2C9, structures thereof and their use
The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide... |
WO/2003/035693A2 | CRYSTALS OF CYTOCHROME P450 2C9, STRUCTURES THEREOF AND THEIR USE
The present invention provides cytochrome 2C9 proteins which have been modified to introduce a proline residue at positions 220 or 222 of the wild type sequence which can be crystallised to provide... |