US20070015270 | Crystalline PDE4D2 catalytic domain complex, and methods for making and employing same
The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure... |
US20070015205 | Crystal structure of phosphodiesterase 5 and use thereof
The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5... |
WO/2005/103241A1 | CRYSTAL STRUCTURE OF 3', 5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 9A (PDE9A) AND USES THEREOF
The present invention related to a crystal structure of a phosphodiesterase 9A (PDE9A)/PDE9A ligand complex and their uses in identifying PDE9A modulators, including PDE9A ligand compounds. The... |
WO/2005/087919A1 | CRYSTAL STRUCTURE OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE (PDE10A) AND USES THEREOF
Crystal structure of phosphodiesterase 10A (PDE10A), and the 3-D atomic coordinates of the PDE10A binding domain, as described and used for the identification of ligands, including PDE10A... |
US20050202550 | Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE10A) and uses thereof
Crystal structure of phosphodiesterase 10A (PDE10A), and the 3-D atomic coordinates of the PDE10A binding domain, as described and used for the identification of ligands, including PDE10A... |
US20050202549 | Crystal structure
The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present... |
WO/2005/083069A1 | PDE2 CRYSTAL STRUCTURES FOR STRUCTURE BASED DRUG DESIGN
Crystalline compositions of Phosphodiesterase Type 2 (PDE2), particularly of the PDE2 catalytic domain, and amino acid sequences utilized to form such crystalline compositions, which are used to... |
US20050079548 | Ligand development using PDE4B crystal structures
The use of PDE4B crystals and strucural information for identifying molecular scaffolds and for developing ligands that bind to and modulate PDE4B is described. |
US20050075795 | Crystal structure of 3', 5'-cyclic nucleotide phosphodiesterase (PDE1B) and uses thereof
Crystal structures of phosphodiesterase 1B (PDE1B), and the 3-D atomic coordinates of the PDE1B binding domain, are described and used to obtain PDE1B ligands, including PDE1B inhibitors. The... |
WO/2004/097010A1 | CRYSTAL OF PDE5, ITS CRYSTAL STRUCTURE AND ITS USE IN DRUG DESIGN
The present invention relates to the soakable crystals of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 ligands and inhibitor compounds. The present... |
WO/2004/087906A1 | CRYSTAL STRUCTURE OF 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (PDE1B) AND USES THEREOF
Crystal structures of phosphodiesterase 1B (PDE1B), and the 3-D atomic coordinates of the PDE1B binding domain, are described and used to obtain PDE1B ligands, including PDE1B inhibitors. The... |
US20040082052 | Crystal structure
The present invention relates to the soakable crystal structures of a phosphodiesterase 5 (PDE5) and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present... |
WO/2003/038080A1 | CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 5 AND USE THEREOF
The present invention relates , inter alia to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5... |